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YOUAH Home » science news » Vaccine-Induced Effector-Memory CD8 T Cell Responses Predict Therapeutic Efficacy against Tumors CELLULAR IMMUNOLOGY AND IMMUNE REGULATION]
Friday, 20 Oct 2017

Vaccine-Induced Effector-Memory CD8 T Cell Responses Predict Therapeutic Efficacy against Tumors CELLULAR IMMUNOLOGY AND IMMUNE REGULATION]

CD8+ T cells have the potential to attack and eradicate cancer cells. The efficacy of therapeutic vaccines against cancer, however, lacks defined immune correlates of tumor eradication after (therapeutic) vaccination based on features of Ag-specific T cell responses. In this study, we examined CD8+ T cell responses elicited by various peptide and TLR agonist-based vaccine formulations in nontumor settings and show that the formation of CD62LKLRG1+ effector-memory CD8+ T cells producing the effector cytokines IFN- and TNF predicts the degree of therapeutic efficacy of these vaccines against established s.c. tumors. Thus, characteristics of vaccine-induced CD8+ T cell responses instill a predictive determinant for the efficacy of vaccines during tumor therapy.

Read more: Vaccine-Induced Effector-Memory CD8 T Cell Responses Predict Therapeutic Efficacy against Tumors CELLULAR IMMUNOLOGY AND IMMUNE REGULATION]

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